Challenges in analysis and interpretation of microsatellite data for population genetic studies.

ABSTRACT: Advancing technologies have facilitated the ever-widening application of genetic markers such as microsatellites into new systems and research questions in biology. In light of the data and experience accumulated from several years of using microsatellites, we present here a literature review that synthesizes the limitations of microsatellites in population genetic studies. With a focus on population structure, we review the widely used fixation (F ST) statistics and Bayesian clustering algorithms and find that the former can be confusing and problematic for microsatellites and that the latter may be confounded by complex population models and lack power in certain cases. Clustering, multivariate analyses, and diversity-based statistics are increasingly being applied to infer population st

SUBMITTER: Putman AI 

PROVIDER: S-EPMC4267876 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature