Quality of life in major depressive disorder before/after multiple steps of treatment and one-year follow-up.

ABSTRACT:

Objective

This study examines the impact of major depressive disorder (MDD) and its treatment on quality of life (QOL).

Method

From the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial, we analyzed complete data of 2280 adult MDD out-patients at entry/exit of each level of antidepressant treatments and after 12 months of entry to follow-up. QOL was measured using the QOL Enjoyment and Satisfaction Questionnaire (Q-LES-Q). The proportions of patients scoring 'within-normal' QOL (within 10% of Q-LES-Q community norms) and those with 'severely impaired' QOL (>2 SD below Q-LES-Q community norms) were analyzed.

Results

Before treatment, no more than 3% of MDD patients experienced 'within-normal' QOL. Following treatment, statistically significant impro

SUBMITTER: IsHak WW 

PROVIDER: S-EPMC4267902 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature