Evidence for stabilizing selection on codon usage in chromosomal rearrangements of Drosophila pseudoobscura.

ABSTRACT: There has been a renewed interest in investigating the role of stabilizing selection acting on genome-wide traits such as codon usage bias. Codon bias, when synonymous codons are used at unequal frequencies, occurs in a wide variety of taxa. Standard evolutionary models explain the maintenance of codon bias through a balance of genetic drift, mutation and weak purifying selection. The efficacy of selection is expected to be reduced in regions of suppressed recombination. Contrary to observations in Drosophila melanogaster, some recent studies have failed to detect a relationship between the recombination rate, intensity of selection acting at synonymous sites, and the magnitude of codon bias as predicted under these standard models. Here, we examined codon bias in 2798 protein coding loci

SUBMITTER: Fuller ZL 

PROVIDER: S-EPMC4267939 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature