Natalizumab-related anaphylactoid reactions in MS patients are associated with HLA class II alleles.

ABSTRACT:

Objectives

We aimed to investigate potential associations between human leukocyte antigen (HLA) class I and class II alleles and the development of anaphylactic/anaphylactoid reactions in patients with multiple sclerosis (MS) treated with natalizumab.

Methods

HLA class I and II genotyping was performed in patients with MS who experienced anaphylactic/anaphylactoid reactions and in patients who did not develop infusion-related allergic reactions following natalizumab administration.

Results

A total of 119 patients with MS from 3 different cohorts were included in the study: 54 with natalizumab-related anaphylactic/anaphylactoid reactions and 65 without allergic reactions. HLA-DRB1*13 and HLA-DRB1*14 alleles were significantly increased in patients who developed anaphyl

SUBMITTER: de la Hera B 

PROVIDER: S-EPMC4268037 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature