Suppressing AP1 factor signaling in the suprabasal epidermis produces a keratoderma phenotype.

ABSTRACT: Keratodermas comprise a heterogeneous group of highly debilitating and painful disorders characterized by thickening of the skin with marked hyperkeratosis. Some of these diseases are caused by genetic mutation, whereas other forms are acquired in response to environmental factors. Our understanding of signaling changes that underlie these diseases is limited. In the present study, we describe a keratoderma phenotype in mice in response to suprabasal epidermis-specific inhibition of activator protein 1 transcription factor signaling. These mice develop a severe phenotype characterized by hyperplasia, hyperkeratosis, parakeratosis, and impaired epidermal barrier function. The skin is scaled, constricting bands encircle the tail and digits, the footpads are thickened and scaled, and loricrin

SUBMITTER: Rorke EA 

PROVIDER: S-EPMC4268309 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature