Liver histology during Mipomersen therapy for severe hypercholesterolemia.

ABSTRACT:

Background

Mipomersen is an antisense oligonucleotide that inhibits apolipoprotein B synthesis and lowers plasma low-density lipoprotein cholesterol even in the absence of low-density lipoprotein receptor function, presumably from inhibition of hepatic production of triglyceride-rich very low-density lipoprotein particles. By virtue of this mechanism, mipomersen therapy commonly results in the development of hepatic steatosis. Because this is frequently accompanied by alanine aminotransferase elevations, concern has arisen that mipomersen could promote the development of steatohepatitis, which could in turn lead to fibrosis and cirrhosis over time.

Objective

The objective of this study was to assess the liver biopsy findings in patients treated with mipomersen.

Methods

SUBMITTER: Hashemi N 

PROVIDER: S-EPMC4268487 | biostudies-literature | 2014 Nov-Dec

REPOSITORIES: biostudies-literature