SPoRE: a mathematical model to predict double strand breaks and axis protein sites in meiosis.

ABSTRACT:

Background

Meiotic recombination between homologous chromosomes provides natural combinations of genetic variations and is a main driving force of evolution. It is initiated via programmed DNA double-strand breaks (DSB) and involves a specific axial chromosomal structure. So far, recombination regions have been mainly determined by experiments, both expensive and time-consuming.

Results

SPoRE is a mathematical model that describes the non-uniform localisation of DSB and axis proteins sites, and distinguishes high versus low protein density. It is based on a combination of genomic signals, based on what is known from wet-lab experiments, whose contribution is precisely quantified. It models axis proteins accumulation at gene 5'-ends with a discrete approximation of their diff

SUBMITTER: Champeimont R 

PROVIDER: S-EPMC4268827 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature