Lack of association between COX-2 8473T>C polymorphism and breast cancer risk: a meta-analysis.

ABSTRACT:

Aim of the study

Results of recent published studies on the association between the COX-2 8473T>C polymorphism and the risk of breast cancer have often been conflicting. To make a more precise estimation of the potential relationship, a meta-analysis was performed.

Material and methods

A total of seven case-control studies with 7,033 cases and 9,350 controls were included in the current meta-analysis through searching the databases of PubMed, Embase, and Cochrane Library (up to March 1(st), 2013). The odds ratio (OR) and 95% confidence interval (95% CI) were calculated to assess the strength of the association. The meta-analysis was conducted in a fixed/random effect model.

Results

We found no significant associations for all genetic models after all studies were pool

SUBMITTER: Jiang J 

PROVIDER: S-EPMC4269000 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature