The ARMS2 A69S variant and bilateral advanced age-related macular degeneration.

ABSTRACT:

Purpose

To identify genetic associations between specific risk genes and bilateral advanced age-related macular degeneration (AMD) in a retrospective, observational case series of 1,003 patients: 173 patients with geographic atrophy in at least 1 eye and 830 patients with choroidal neovascularization in at least 1 eye.

Methods

Patients underwent clinical examination and fundus photography. The images were subsequently graded using a modified grading system adapted from the Age-Related Eye Disease Study. Genetic analysis was performed to identify genotypes at 4 AMD-associated variants (ARMS2 A69S, CFH Y402H, C3 R102G, and CFB R32Q) in these patients.

Results

There were no statistically significant relationships between clinical findings and genotypes at CFH, C3, and CF

SUBMITTER: Schwartz SG 

PROVIDER: S-EPMC4269218 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature