Genetic polymorphisms involved in folate metabolism and maternal risk for down syndrome: a meta-analysis.

ABSTRACT: Inconclusive results of the association between genetic polymorphisms involved in folate metabolism and maternal risk for Down syndrome (DS) have been reported. Therefore, this meta-analysis was conducted. We searched electronic databases through May, 2014, for eligible studies. Pooled odds ratios with 95% confidence intervals were used to assess the strength of the association, which was estimated by fixed or random effects models. Heterogeneity among studies was evaluated using Q-test and I (2) statistic. Subgroup and sensitivity analyses were also conducted. Publication bias was estimated using Begg's and Egger's tests. A total of 17 case-controls studies were included. There was evidence for an association between the MTRR c.66A>G (rs1801394) polymorphism and maternal risk for DS. In t

SUBMITTER: Balduino Victorino D 

PROVIDER: S-EPMC4269293 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature