Animal models of bronchopulmonary dysplasia. The preterm baboon models.

ABSTRACT: Much of the progress in improved neonatal care, particularly management of underdeveloped preterm lungs, has been aided by investigations of multiple animal models, including the neonatal baboon (Papio species). In this article we highlight how the preterm baboon model at both 140 and 125 days gestation (term equivalent 185 days) has advanced our understanding and management of the immature human infant with neonatal lung disease. Not only is the 125-day baboon model extremely relevant to the condition of bronchopulmonary dysplasia but there are also critical neurodevelopmental and other end-organ pathological features associated with this model not fully discussed in this limited forum. We also describe efforts to incorporate perinatal infection into these preterm models, both fetal and n

SUBMITTER: Yoder BA 

PROVIDER: S-EPMC4269686 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature