Genome-wide association study of lung function phenotypes in a founder population.

ABSTRACT:

Background

Lung function is a long-term predictor of mortality and morbidity.

Objective

We sought to identify single nucleotide polymorphisms (SNPs) associated with lung function.

Methods

We performed a genome-wide association study (GWAS) of FEV1, forced vital capacity (FVC), and FEV1/FVC in 1144 Hutterites aged 6 to 89 years, who are members of a founder population of European descent. We performed least absolute shrinkage and selection operation regression to select the minimum set of SNPs that best predict FEV1/FVC in the Hutterites and used the GRAIL algorithm to mine the Gene Ontology database for evidence of functional connections between genes near the predictive SNPs.

Results

Our GWAS identified significant associations between FEV1/FVC and SNPs at the

SUBMITTER: Yao TC 

PROVIDER: S-EPMC4270121 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature