Evolutionary acquisition of cysteines determines FOXO paralog-specific redox signaling.

ABSTRACT:

Unlabelled

Reduction-oxidation (redox) signaling, the translation of an oxidative intracellular environment into a cellular response, is mediated by the reversible oxidation of specific cysteine thiols. The latter can result in disulfide formation between protein hetero- or homodimers that alter protein function until the local cellular redox environment has returned to the basal state. We have previously shown that this mechanism promotes the nuclear localization and activity of the Forkhead Box O4 (FOXO4) transcription factor.

Aims

In this study, we sought to investigate whether redox signaling differentially controls the human FOXO3 and FOXO4 paralogs.

Results

We present evidence that FOXO3 and FOXO4 have acquired paralog-specific cysteines throughout vertebrate ev

SUBMITTER: Putker M 

PROVIDER: S-EPMC4270166 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature