Potential therapeutic mechanism of genistein in breast cancer involves inhibition of cell cycle regulation.

ABSTRACT: Genistein can prevent tumorigenesis and reduce the incidence of diseases that are dependent upon estrogen. Previous research, however, has shown that genistein can also increase the risk of breast cancer. Thus, the aim of the present study was to investigate the mechanism underlying the effect of genistein in breast cancer and to determine whether genistein produces a therapeutic effect or promotes the development of breast cancer. Gene microarray data obtained from three samples treated with alcohol (control group), three samples treated with 3 µmol/l genistein and three samples treated with 10 µmol/l genistein for 48 h, were downloaded from the Gene Expression Omnibus database. Analysis of the differentially expressed genes (DEGs) and functional enrichment in the two genistein groups was

SUBMITTER: Zhang L 

PROVIDER: S-EPMC4270317 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature