Genetic basis of haloperidol resistance in Saccharomyces cerevisiae is complex and dose dependent.

ABSTRACT: The genetic basis of most heritable traits is complex. Inhibitory compounds and their effects in model organisms have been used in many studies to gain insights into the genetic architecture underlying quantitative traits. However, the differential effect of compound concentration has not been studied in detail. In this study, we used a large segregant panel from a cross between two genetically divergent yeast strains, BY4724 (a laboratory strain) and RM11_1a (a vineyard strain), to study the genetic basis of variation in response to different doses of a drug. Linkage analysis revealed that the genetic architecture of resistance to the small-molecule therapeutic drug haloperidol is highly dose-dependent. Some of the loci identified had effects only at low doses of haloperidol, while other

SUBMITTER: Wang X 

PROVIDER: S-EPMC4270474 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature