Comparison of the gene expression profiles between gallstones and gallbladder polyps.

ABSTRACT:

Background

Gallstones and gallbladder polyps (GPs) are two major types of gallbladder diseases that share multiple common symptoms. However, their pathological mechanism remains largely unknown. The aim of our study is to identify gallstones and GPs related-genes and gain an insight into the underlying genetic basis of these diseases.

Methods

We enrolled 7 patients with gallstones and 2 patients with GP for RNA-Seq and we conducted functional enrichment analysis and protein-protein interaction (PPI) networks analysis for identified differentially expressed genes (DEGs).

Results

RNA-Seq produced 41.7 million in gallstones and 32.1 million pairs in GPs. A total of 147 DEGs was identified between gallstones and GPs. We found GO terms for molecular functions significantly

SUBMITTER: Li Q 

PROVIDER: S-EPMC4270579 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature