The effects of purifying selection on patterns of genetic differentiation between Drosophila melanogaster populations.

ABSTRACT: Using the data provided by the Drosophila Population Genomics Project, we investigate factors that affect the genetic differentiation between Rwandan and French populations of D. melanogaster. By examining within-population polymorphisms, we show that sites in long introns (especially those >2000 bp) have significantly lower π (nucleotide diversity) and more low-frequency variants (as measured by Tajima's D, minor allele frequencies, and prevalence of variants that are private to one of the two populations) than short introns, suggesting a positive relationship between intron length and selective constraint. A similar analysis of protein-coding polymorphisms shows that 0-fold (degenerate) sites in more conserved genes are under stronger purifying selection than those in less conserved gene

SUBMITTER: Jackson BC 

PROVIDER: S-EPMC4270736 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature