Cellular oxidative stress response controls the antiviral and apoptotic programs in dengue virus-infected dendritic cells.

ABSTRACT: Dengue virus (DENV) is a re-emerging arthropod borne flavivirus that infects more than 300 million people worldwide, leading to 50,000 deaths annually. Because dendritic cells (DC) in the skin and blood are the first target cells for DENV, we sought to investigate the early molecular events involved in the host response to the virus in primary human monocyte-derived dendritic cells (Mo-DC). Using a genome-wide transcriptome analysis of DENV2-infected human Mo-DC, three major responses were identified within hours of infection - the activation of IRF3/7/STAT1 and NF-κB-driven antiviral and inflammatory networks, as well as the stimulation of an oxidative stress response that included the stimulation of an Nrf2-dependent antioxidant gene transcriptional program. DENV2 infection resulted in t

SUBMITTER: Olagnier D 

PROVIDER: S-EPMC4270780 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature