Human plasma lipidome is pleiotropically associated with cardiovascular risk factors and death.

ABSTRACT:

Background

Cardiovascular disease (CVD) is the most common cause of death in the United States and is associated with a high economic burden. Prevention of CVD focuses on controlling or improving the lipid profile of patients at risk. The human lipidome is made up of thousands of ubiquitous lipid species. By studying biologically simple canonical lipid species, we investigated whether the lipidome is genetically redundant and whether its genetic influences can provide clinically relevant clues of CVD risk.

Methods and results

We performed a genetic study of the human lipidome in 1212 individuals from 42 extended Mexican American families. High-throughput mass spectrometry enabled rapid capture of precise lipidomic profiles, providing 319 unique species. Using variance compon

SUBMITTER: Bellis C 

PROVIDER: S-EPMC4270876 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature