Ontology highlight
ABSTRACT:
SUBMITTER: Astarita JL
PROVIDER: S-EPMC4270928 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Nature immunology 20141027 1
In lymph nodes, fibroblastic reticular cells (FRCs) form a collagen-based reticular network that supports migratory dendritic cells (DCs) and T cells and transports lymph. A hallmark of FRCs is their propensity to contract collagen, yet this function is poorly understood. Here we demonstrate that podoplanin (PDPN) regulates actomyosin contractility in FRCs. Under resting conditions, when FRCs are unlikely to encounter mature DCs expressing the PDPN receptor CLEC-2, PDPN endowed FRCs with contrac ...[more]