Rapid disease progression in HIV-1 subtype C-infected South African women.

ABSTRACT:

Background

Whereas human immunodeficiency virus (HIV) subtype B-infected individuals generally progress to AIDS within 8-10 years, limited data exist for other clades, especially from Africa. We investigated rates of HIV disease progression of clade C-infected South African women.

Methods

Prospective seroincidence cohorts in KwaZulu-Natal were assessed for acute HIV infection monthly (n = 245) or every 3 months (n = 594) for up to 4 years. Rapid disease progression was defined as CD4 decline to <350 cells/µL by 2 years postinfection. Serial clinical and laboratory assessments were compared using survival analysis and logistic regression models.

Results

Sixty-two women were identified at a median of 42 days postinfection (interquartile range, 34-59), contributing 282 p

SUBMITTER: Mlisana K 

PROVIDER: S-EPMC4271037 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature