Performance of self-collected cervical samples in screening for future precancer using human papillomavirus DNA testing.

ABSTRACT:

Background

Self-collected human papillomavirus (HPV) testing could reduce barriers to cervical cancer screening, with performance comparable to clinician-collected specimens. The ability of self-collected specimens to cross-sectionally and prospectively detect precursor lesions was investigated in an HPV vaccine randomized trial in Costa Rica.

Methods

In the trial, 7466 women age 18 to 25 years received an HPV16/18 or control vaccine and were followed at least annually for four years. In this secondary analysis, we included all women who provided a self-collected cervicovaginal specimen six months after enrollment (5109 women = full analytical cohort). A subset (615 women = restricted cohort) also had clinician-collected specimens at the six-month postenrollment visit. High-

SUBMITTER: Porras C 

PROVIDER: S-EPMC4271079 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature