Genetic variation in the tissue factor gene is associated with clinical outcome in severe sepsis patients.

ABSTRACT:

Introduction

Activation of inflammation and coagulation was closely related and mutually interdependent in sepsis. Tissue factor (TF) and its endogenous inhibitor, tissue factor pathway inhibitor (TFPI) was the main regulators of the initiation of coagulation process. Altered plasma levels of TF and TFPI have been related to worse outcome in sepsis. The objective of this study was to investigate whether single nucleotide polymorphisms (SNPs) in the TF and TFPI genes were associated with risk and outcome for patients with severe sepsis.

Methods

Seventeen SNPs in TF and TFPI were genotyped in samples of sepsis (n =577) and severe sepsis patients (n =476), and tested for association in this case-control collection. We then investigated correlation between the associated SNPs an

SUBMITTER: Shi D 

PROVIDER: S-EPMC4271362 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature