Reassortment between influenza B lineages and the emergence of a coadapted PB1-PB2-HA gene complex.

ABSTRACT: Influenza B viruses make a considerable contribution to morbidity attributed to seasonal influenza. Currently circulating influenza B isolates are known to belong to two antigenically distinct lineages referred to as B/Victoria and B/Yamagata. Frequent exchange of genomic segments of these two lineages has been noted in the past, but the observed patterns of reassortment have not been formalized in detail. We investigate interlineage reassortments by comparing phylogenetic trees across genomic segments. Our analyses indicate that of the eight segments of influenza B viruses only segments coding for polymerase basic 1 and 2 (PB1 and PB2) and hemagglutinin (HA) proteins have maintained separate Victoria and Yamagata lineages and that currently circulating strains possess PB1, PB2, and HA seg

SUBMITTER: Dudas G 

PROVIDER: S-EPMC4271528 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature