Multicenter outbreak of infections by Saprochaete clavata, an unrecognized opportunistic fungal pathogen.

ABSTRACT:

Unlabelled

Rapidly fatal cases of invasive fungal infections due to a fungus later identified as Saprochaete clavata were reported in France in May 2012. The objectives of this study were to determine the clonal relatedness of the isolates and to investigate possible sources of contamination. A nationwide alert was launched to collect cases. Molecular identification methods, whole-genome sequencing (WGS), and clone-specific genotyping were used to analyze recent and historical isolates, and a case-case study was performed. Isolates from thirty cases (26 fungemias, 22 associated deaths at day 30) were collected between September 2011 and October 2012. Eighteen cases occurred within 8 weeks (outbreak) in 10 health care facilities, suggesting a common source of contamination, with pot

SUBMITTER: Vaux S 

PROVIDER: S-EPMC4271555 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature