Genome-Wide Mapping of Chromatin State of Mouse Forelimbs.

ABSTRACT:

Background

Cell types are defined at the molecular level during embryogenesis by a process called pattern formation and created by the selective utilization of combinations of sequence specific transcription factors. Developmental programs define the sets of genes that are available to each particular cell type, and real-time biochemical signaling interactions define the extent to which these sets are used at any given time and place. Gene expression is regulated through the integrated action of many cis-regulatory elements, including core promoters, enhancers, silencers, and insulators. The chromatin state in developing body parts provides a code to cellular populations that direct their cell fates. Chromatin profiling has been a method of choice for mapping regulatory sequ

SUBMITTER: Eng D 

PROVIDER: S-EPMC4271808 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature