Novel sequence variations in the brain-derived neurotrophic factor gene and association with major depression and antidepressant treatment response.

ABSTRACT:

Context

Variations in the brain-derived neurotrophic factor gene (BDNF) have been associated with psychiatric disorders. Deep sequencing of the BDNF gene may identify new variations and bring further insight into psychiatric genetics.

Objective

To better characterize sequence variability in the BDNF gene by resequencing a genomic DNA region of 22 kilobases that contained all BDNF exons and their flanking regions.

Design

Case-control study.

Setting

University of California, Los Angeles, and University of Miami.

Participants

Two hundred sixty-four controls and 272 Mexican Americans with major depressive disorder (MDD) from Los Angeles who were assessed by the same bilingual clinical research team.

Main outcome measures

Identification of novel geneti

SUBMITTER: Licinio J 

PROVIDER: S-EPMC4272010 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature