Effects of recombinant human type I pancreatic elastase on human atherosclerotic arteries.

ABSTRACT:

Rationale

At physiologic pressures, elastic fibers constrain artery diameter. Local treatment of atherosclerotic arteries with PRT-201, a recombinant type I elastase, could result in fragmentation and removal of elastin fibers and increased vessel diameter.

Objective

To investigate the use of PRT-201 as a treatment for human atherosclerotic arteries.

Methods and results

Arteries were harvested from donor legs amputated due to severe peripheral artery disease or from recently deceased persons who donated their bodies to science. Three- to four-centimeter artery segments were studied on a perfusion myograph to obtain baseline diameter data. After treatment with PRT-201 3.6 mg/mL or saline for 30 minutes myography was repeated. PRT-201 treatment resulted in an increase i

SUBMITTER: Burke SK 

PROVIDER: S-EPMC4272232 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature