Distribution and clinical correlates of viral and host genotypes in Chinese patients with chronic hepatitis C virus infection.

ABSTRACT:

Background and aim

Chronic hepatitis C virus (HCV) infection is relatively frequent in China. This study investigated the clinical, demographic, and viral and host genetic characteristics that may influence disease manifestations and clinical management.

Methods

In this cross-sectional observational study, treatment-naïve Han ethnic adults with recently confirmed chronic HCV infection were enrolled at 28 hospitals across China. HCV genotype and host interleukin 28B (IL28B) genotypes were determined and compared with patient demographic parameters and medical status.

Results

Among the 997 HCV-positive patients analyzed, 56.8% were infected with HCV genotype 1b, followed in prevalence by genotypes 2, 3, and 6, with substantial regional variation. Overall, 84.1% of patie

SUBMITTER: Rao H 

PROVIDER: S-EPMC4272577 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature