Transposable elements modulate human RNA abundance and splicing via specific RNA-protein interactions.

ABSTRACT:

Background

Transposable elements (TEs) have significantly influenced the evolution of transcriptional regulatory networks in the human genome. Post-transcriptional regulation of human genes by TE-derived sequences has been observed in specific contexts, but has yet to be systematically and comprehensively investigated. Here, we study a collection of 75 CLIP-Seq experiments mapping the RNA binding sites for a diverse set of 51 human proteins to explore the role of TEs in post-transcriptional regulation of human mRNAs and lncRNAs via RNA-protein interactions.

Results

We detect widespread interactions between RNA binding proteins (RBPs) and many families of TE-derived sequence in the CLIP-Seq data. Further, alignment coverage peaks on specific positions of the TE consensus sequ

SUBMITTER: Kelley DR 

PROVIDER: S-EPMC4272801 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature