Helminth infection alters IgE responses to allergens structurally related to parasite proteins.

ABSTRACT: Immunological cross-reactivity between environmental allergens and helminth proteins has been demonstrated, although the clinically related implications of this cross-reactivity have not been addressed. To investigate the impact of molecular similarity among allergens and cross-reactive homologous helminth proteins in IgE-based serologic assessment of allergic disorders in a helminth-infected population, we performed ImmunoCAP tests in filarial-infected and noninfected individuals for IgE measurements to allergen extracts that contained proteins with high levels of homology with helminth proteins as well as IgE against representative recombinant allergens with and without helminth homologs. The impact of helminth infection on the levels and function of the IgE to these specific homologous

SUBMITTER: Santiago Hda C 

PROVIDER: S-EPMC4272869 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature