The gut wall provides an effective barrier against nanoparticle uptake.

ABSTRACT:

Background

The omnipresence of nanoparticles (NPs) in numerous goods has led to a constant risk of exposure and inadvertent uptake for humans. This situation calls for thorough investigation of the consequences of NP intake. As the vast mucosa of the human gastrointestinal tract represents an attractive site of entry, we wanted to take a look on the fate that ingested NPs suffer in the gut. As a model to investigate NP uptake we used the isolated perfused rat small intestine. Differently sized fluorescent latex particles were used as exemplary anthropogenic NPs.

Results

The particles were administered as bolus into the isolated intestine, and samples from the luminal, vascular and lymphatic compartments were collected over time. NP amounts in the different fluids were determ

SUBMITTER: Sinnecker H 

PROVIDER: S-EPMC4273221 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature