Morita-Baylis-Hillman reaction of acrylamide with isatin derivatives.

ABSTRACT: The Morita-Baylis-Hillman reaction of acrylamide, as an activated alkene, has seen little development due to its low reactivity. We have developed the reaction using isatin derivatives with acrylamide, DABCO as a promoter and phenol as an additive in acetonitrile. The corresponding aza version with acrylate and acrylonitrile has also been developed resulting in high product yields.

SUBMITTER: Singh RM 

PROVIDER: S-EPMC4273229 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature