Prospective multicenter evaluation of the Beckman Coulter Prostate Health Index using WHO calibration.

ABSTRACT:

Purpose

Reported prostate specific antigen values may differ substantially among assays using Hybritech® or WHO standardization. The Beckman Coulter® Prostate Health Index and [-2]proPSA are newly approved serum markers associated with prostate cancer risk and aggressiveness. We studied the influence of assay standardization on these markers.

Materials and methods

Prostate specific antigen, percent free prostate specific antigen and [-2]proPSA were measured using Hybritech calibration in 892 men from a prospective, multicenter study undergoing prostate biopsy. We calculated the Prostate Health Index using the equation, ([-2]proPSA/free prostate specific antigen) × PSA. Index performance characteristics for prostate cancer detection were then determined using recalculated WHO

SUBMITTER: Loeb S 

PROVIDER: S-EPMC4273580 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature