Optimized delivery system achieves enhanced endomyocardial stem cell retention.

ABSTRACT:

Background

Regenerative cell-based therapies are associated with limited myocardial retention of delivered stem cells. The objective of this study is to develop an endocardial delivery system for enhanced cell retention.

Methods and results

Stem cell retention was simulated in silico using 1- and 3-dimensional models of tissue distortion and compliance associated with delivery. Needle designs, predicted to be optimal, were accordingly engineered using nitinol, a nickel and titanium alloy displaying shape memory and superelasticity. Biocompatibility was tested with human mesenchymal stem cells. Experimental validation was performed with species-matched cells directly delivered into Langendorff-perfused porcine hearts or administered percutaneously into the endocardium of infa

SUBMITTER: Behfar A 

PROVIDER: S-EPMC4273747 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature