Cathelicidin suppresses colon cancer development by inhibition of cancer associated fibroblasts.

ABSTRACT:

Background

Cathelicidin (LL-37 in humans and mCRAMP in mice) represents a family of endogenous antimicrobial and anti-inflammatory peptides. Cancer-associated fibroblasts can promote the proliferation of colon cancer cells and growth of colon cancer tumors.

Methods

We examined the role of cathelicidin in the development of colon cancer, using subcutaneous human HT-29 colon-cancer-cell-derived tumor model in nude mice and azoxymethane- and dextran sulfate-mediated colon cancer model in C57BL/6 mice. We also determined the indirect antitumoral mechanism of cathelicidin via the inhibition of epithelial-mesenchymal transition (EMT) of colon cancer cells and fibroblast-supported colon cancer cell proliferation.

Results

Intravenous administration of cathelicidin expressing

SUBMITTER: Cheng M 

PROVIDER: S-EPMC4274046 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature