Amygdala-cingulate intrinsic connectivity is associated with degree of social inhibition.

ABSTRACT: The tendency to approach or avoid novel people is a fundamental human behavior and is a core dimension of social anxiety. Resting state fMRI was used to test for an association between social inhibition and intrinsic connectivity in 40 young adults ranging from low to high in social inhibition. Higher levels of social inhibition were associated with specific patterns of reduced amygdala-cingulate cortex connectivity. Connectivity was reduced between the superficial amygdala and the rostral cingulate cortex and between the centromedial amygdala and the dorsal anterior cingulate cortex. Social inhibition also modulated connectivity in several well-established intrinsic networks; higher social inhibition correlated with reduced connectivity with default mode and dorsal attention networks and

SUBMITTER: Blackford JU 

PROVIDER: S-EPMC4274047 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature