Association between molecular subtypes of colorectal cancer and patient survival.

ABSTRACT:

Background and aims

Colorectal cancer (CRC) is a heterogeneous disease that can develop via several pathways. Different CRC subtypes, identified based on tumor markers, have been proposed to reflect these pathways. We evaluated the significance of these previously proposed classifications to survival.

Methods

Participants in the population-based Seattle Colon Cancer Family Registry were diagnosed with invasive CRC from 1998 through 2007 in western Washington State (N = 2706), and followed for survival through 2012. Tumor samples were collected from 2050 participants and classified into 5 subtypes based on combinations of tumor markers: type 1 (microsatellite instability [MSI]-high, CpG island methylator phenotype [CIMP] -positive, positive for BRAF mutation, negative for KRA

SUBMITTER: Phipps AI 

PROVIDER: S-EPMC4274235 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature