The role of the medial prefrontal cortex in trace fear extinction.

ABSTRACT: The extinction of delay fear conditioning relies on a neural circuit that has received much attention and is relatively well defined. Whether this established circuit also supports the extinction of more complex associations, however, is unclear. Trace fear conditioning is a better model of complex relational learning, yet the circuit that supports extinction of this memory has received very little attention. Recent research has indicated that trace fear extinction requires a different neural circuit than delay extinction; trace extinction requires the participation of the retrosplenial cortex, but not the amygdala, as noted in a previous study. Here, we tested the roles of the prelimbic and infralimbic regions of the medial prefrontal cortex in trace and delay fear extinction by blocking

SUBMITTER: Kwapis JL 

PROVIDER: S-EPMC4274329 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature