Transcriptome meta-analysis of lung cancer reveals recurrent aberrations in NRG1 and Hippo pathway genes.
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ABSTRACT:
SUBMITTER: Dhanasekaran SM
PROVIDER: S-EPMC4274748 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Publications
Transcriptome meta-analysis of lung cancer reveals recurrent aberrations in NRG1 and Hippo pathway genes.
Dhanasekaran Saravana M SM Balbin O Alejandro OA Chen Guoan G Nadal Ernest E Kalyana-Sundaram Shanker S Pan Jincheng J Veeneman Brendan B Cao Xuhong X Malik Rohit R Vats Pankaj P Wang Rui R Huang Stephanie S Zhong Jinjie J Jing Xiaojun X Iyer Matthew M Wu Yi-Mi YM Harms Paul W PW Lin Jules J Reddy Rishindra R Brennan Christine C Palanisamy Nallasivam N Chang Andrew C AC Truini Anna A Truini Mauro M Robinson Dan R DR Beer David G DG Chinnaiyan Arul M AM
Nature communications 20141222
Lung cancer is emerging as a paradigm for disease molecular subtyping, facilitating targeted therapy based on driving somatic alterations. Here we perform transcriptome analysis of 153 samples representing lung adenocarcinomas, squamous cell carcinomas, large cell lung cancer, adenoid cystic carcinomas and cell lines. By integrating our data with The Cancer Genome Atlas and published sources, we analyse 753 lung cancer samples for gene fusions and other transcriptomic alterations. We show that h ...[more]
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