Hemoglobin a1c and the progression of coronary artery calcification among adults without diabetes.

ABSTRACT:

Objective

Higher levels of hemoglobin A1c (HbA1c) are associated with increased cardiovascular disease risk among individuals without diabetes and may also be positively associated with coronary artery calcification (CAC). This study investigated the association of HbA1c with CAC progression in the Coronary Artery Risk Development in Young Adults study.

Research design and methods

We included 2,076 participants with HbA1c and noncontrast computed tomography (CT) assessed at baseline (2005-2006), and CT repeated 5 years later (2010-2011). CAC progression was defined as 1) incident CAC (increase >0 Agatston units among those with no CAC at baseline), 2) any CAC progression (increase >10 Agatston units between examinations), and 3) advanced CAC progression (increase >100 Agatst

SUBMITTER: Carson AP 

PROVIDER: S-EPMC4274774 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature