Neuronal T-cell autoreactivity is amplified in overweight children with new-onset insulin-requiring diabetes.

ABSTRACT:

Objective

Disease-associated T-cell autoreactivities are seen in most type 1 diabetic patients and are thought to emerge before islet autoantibodies, but host factors that impact autoimmune elements remain uncertain. We assessed if adiposity and measures of insulin sensitivity impact T- and B-cell autoimmunity in children with insulin-requiring diabetes.

Research design and methods

Insulin-requiring children and adolescents diagnosed between January 2004 and June 2008 were studied (n = 261): age 9.7 ± 4 years, 92% white, and 60% male. T-cell responses to 10 diabetes-associated antigens, β-cell autoantibodies (GADA, IA-2A, IAA, and ICA), BMI z score (BMIz), and waist percentile were measured at onset and 3 months later.

Results

All but one subject had either T- or B-ce

SUBMITTER: Buryk MA 

PROVIDER: S-EPMC4274776 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature