Biomarkers in fasting serum to estimate glucose tolerance, insulin sensitivity, and insulin secretion.

ABSTRACT:

Background

Biomarkers for estimating reduced glucose tolerance, insulin sensitivity, or impaired insulin secretion would be clinically useful, since these physiologic measures are important in the pathogenesis of type 2 diabetes mellitus.

Methods

We conducted a cross-sectional study in which 94 individuals, of whom 84 had 1 or more risk factors and 10 had no known risk factors for diabetes, underwent oral glucose tolerance testing. We measured 34 protein biomarkers associated with diabetes risk in 250-μL fasting serum samples. We applied multiple regression selection techniques to identify the most informative biomarkers and develop multivariate models to estimate glucose tolerance, insulin sensitivity, and insulin secretion. The ability of the glucose tolerance model to dis

SUBMITTER: Goldfine AB 

PROVIDER: S-EPMC4274783 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature