Intrastriatal transplantation of adult human neural crest-derived stem cells improves functional outcome in parkinsonian rats.

ABSTRACT: Parkinson's disease (PD) is considered the second most frequent and one of the most severe neurodegenerative diseases, with dysfunctions of the motor system and with nonmotor symptoms such as depression and dementia. Compensation for the progressive loss of dopaminergic (DA) neurons during PD using current pharmacological treatment strategies is limited and remains challenging. Pluripotent stem cell-based regenerative medicine may offer a promising therapeutic alternative, although the medical application of human embryonic tissue and pluripotent stem cells is still a matter of ethical and practical debate. Addressing these challenges, the present study investigated the potential of adult human neural crest-derived stem cells derived from the inferior turbinate (ITSCs) transplanted into a

SUBMITTER: Muller J 

PROVIDER: S-EPMC4275008 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature