Antipathogen genes and the replacement of disease-vectoring mosquito populations: a model-based evaluation.

ABSTRACT: Recently, genetic strategies aimed at controlling populations of disease-vectoring mosquitoes have received considerable attention as alternatives to traditional measures. Theoretical studies have shown that female-killing (FK), antipathogen (AP), and reduce and replace (R&R) strategies can each decrease the number competent vectors. In this study, we utilize a mathematical model to evaluate impacts on competent Aedes aegypti populations of FK, AP, and R&R releases as well as hybrid strategies that result from combinations of these three approaches. We show that while the ordering of efficacy of these strategies depends upon population life history parameters, sex ratio of releases, and switch time in combination strategies, AP-only and R&R/AP releases typically lead to the greatest long-t

SUBMITTER: Robert MA 

PROVIDER: S-EPMC4275095 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature