Evaluation of intradural stimulation efficiency and selectivity in a computational model of spinal cord stimulation.

ABSTRACT: Spinal cord stimulation (SCS) is an alternative or adjunct therapy to treat chronic pain, a prevalent and clinically challenging condition. Although SCS has substantial clinical success, the therapy is still prone to failures, including lead breakage, lead migration, and poor pain relief. The goal of this study was to develop a computational model of SCS and use the model to compare activation of neural elements during intradural and extradural electrode placement. We constructed five patient-specific models of SCS. Stimulation thresholds predicted by the model were compared to stimulation thresholds measured intraoperatively, and we used these models to quantify the efficiency and selectivity of intradural and extradural SCS. Intradural placement dramatically increased stimulation efficie

SUBMITTER: Howell B 

PROVIDER: S-EPMC4275184 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature