Two-stage genome-wide search for epistasis with implementation to Recombinant Inbred Lines (RIL) populations.

ABSTRACT:

Objective and methods

This paper proposes an inegrative two-stage genome-wide search for pairwise epistasis on expression quantitative trait loci (eQTL). The traits are clustered into multi-trait complexes that account for correlations between them that may result from common epistasis effects. The search is done by first screening for epistatic regions and then using dense markers within the identified regions, resulting in substantial reduction in the number of tests for epistasis. The FDR is controlled using a hierarchical procedure that accounts for the search structure. Each combination of trait and marker-pair is tested using a model that accounts for both statistical and functional interpretations of epistasis and considers orthogonal effects, such that their contributions t

SUBMITTER: Goldstein P 

PROVIDER: S-EPMC4275240 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature