Glucocerebrosidase gene mutations associated with Parkinson's disease: a meta-analysis in a Chinese population.

ABSTRACT: Mutations of glucocerebrosidase (GBA) confer susceptibility to Parkinson's disease in several ethnical populations, with a high incidence especially in the Ashkenazi Jewish population. Although there are several studies that have investigated a similar association in a Chinese population, small sample sizes and few positive outcomes have made it difficult to obtain conclusive results from these individual studies. Therefore, the present study used a meta-analysis approach, pooling the appropriate data from published studies to investigate the association of GBA mutations and Parkinson's disease in a Chinese population. Nine studies containing 6536 Chinese subjects (3438 cases and 3098 healthy controls) and examining the GBA mutations of L444P, N370S and several other mutations were include

SUBMITTER: Chen J 

PROVIDER: S-EPMC4275276 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature