Role of flippases, scramblases and transfer proteins in phosphatidylserine subcellular distribution.

ABSTRACT: It is well known that lipids are heterogeneously distributed throughout the cell. Most lipid species are synthesized in the endoplasmic reticulum (ER) and then distributed to different cellular locations in order to create the distinct membrane compositions observed in eukaryotes. However, the mechanisms by which specific lipid species are trafficked to and maintained in specific areas of the cell are poorly understood and constitute an active area of research. Of particular interest is the distribution of phosphatidylserine (PS), an anionic lipid that is enriched in the cytosolic leaflet of the plasma membrane. PS transport occurs by both vesicular and non-vesicular routes, with members of the oxysterol-binding protein family (Osh6 and Osh7) recently implicated in the latter route. In add

SUBMITTER: Hankins HM 

PROVIDER: S-EPMC4275391 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature