Associations between menarche-related genetic variants and pubertal growth in male and female adolescents.

ABSTRACT:

Purpose

Previous studies have identified novel genetic variants associated with age at menarche in females of European descent. The pubertal growth effects of these variants have not been carefully evaluated in non-European descent groups. We aimed to examine the effects of 31 newly identified menarche-related single-nucleotide polymorphisms (SNPs) on growth outcomes in African-American (AA) and European-American (EA) children in a prospective cohort.

Methods

We analyzed longitudinal data collected from 263 AAs and 338 EAs enrolled between ages 5 and 17 years; the subjects were followed semiannually for an average of 6 years. The associations between the SNPs and growth-related outcomes, including weight, height, and body mass index (BMI), were examined using mixed-effect mo

SUBMITTER: Tu W 

PROVIDER: S-EPMC4275397 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature